External validity of randomized controlled trials in COPD
نویسندگان
چکیده
منابع مشابه
Blindness in Randomized Controlled Trials
In combination with randomization, blinding or masking is an important factor in randomized controlled trials (RCTs), particularly in trials that assess therapeutic effects. Here an attempt is made to explain blindness and why it is important. In clinical trials, blinding is defined as the condition imposed on a study in which study participants, health care providers and assessors collecting o...
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Background: Chronic obstructive pulmonary disease (COPD) is a major health dilemma and cause of morbidity and mortality in either industrialized or developing countries and inhaled corticosteroids are widely used worldwide in these patients. In this systematic review, we aimed to analyze the effectiveness of these gents compared to placebo. Methods: Pubmed and Google Scholar literature search ...
متن کاملExternal validity of randomised controlled trials in idiopathic pulmonary fibrosis
I would like to propose some concerns, which could affect the external validity of randomised controlled trials in IPF [2, 3]. The first concern is about the diagnostic accuracy of the disease. IPF is a rare disease and no single accurate test for the diagnosis of IPF exists. Studies of the accuracy of diagnosing IPF are performed mostly in tertiary referral centres, and, even in these studies,...
متن کاملExternal validity of randomised controlled trials in idiopathic pulmonary fibrosis.
I would like to propose some concerns, which could affect the external validity of randomised controlled trials in IPF [2, 3]. The first concern is about the diagnostic accuracy of the disease. IPF is a rare disease and no single accurate test for the diagnosis of IPF exists. Studies of the accuracy of diagnosing IPF are performed mostly in tertiary referral centres, and, even in these studies,...
متن کاملThe external validity of published randomized controlled trials in primary care
BACKGROUND A criticism of Randomized Controlled Trials (RCTs) in primary care is that they lack external validity, participants being unrepresentative of the wider population. Our aim was to determine whether published primary care-based RCTs report information about how the study sample is assembled, and whether this is associated with RCT characteristics. METHODS We reviewed RCTs published ...
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ژورنال
عنوان ژورنال: Respiratory Medicine
سال: 2007
ISSN: 0954-6111
DOI: 10.1016/j.rmed.2006.10.011